CROSS-Physis
CROSS-Physis is a translational PhD research project exploring how surgical implants that cross the growth plate (physis) influence bone growth and shape during skeletal development.
Using a juvenile large-animal model, the project investigates the effects of intramedullary implants traversing the distal femoral physis on longitudinal growth, three-dimensional bone morphology, and alignment. By combining paired within-animal comparisons with advanced 3D imaging, surface registration, and quantitative morphometric analysis, CROSS-Physis provides a comprehensive assessment of how controlled physeal violation affects growing bone.
A key focus of the project is the comparison of implant materials, specifically titanium versus stainless steel, to determine whether material properties influence physeal response and growth outcomes.
The ultimate goal of CROSS-Physis is to generate high-quality experimental evidence that informs safer surgical strategies in pediatric orthopedics, helping surgeons balance fracture stability with preservation of normal growth.
Main researcher:
Co-researchers from the group:
Ole Rahbek, John Rasmussen, Shima Gholinezhad
External Co-researchers:
Jan Duedal Rölfing
Supported by:
-
First study of the PhD project, with aim to map the literature on the effects of growth plate violation with intramedullary locking nail (IMN) at the knee in skeletally immature patients. It focused on assessing clinical and experimental outcomes, with particular attention to complications such as growth arrest and deformities.
Read full text here